Invasive squamous cell carcinoma arising from an intraductal oncocytic papillary neoplasm demonstrating shared ATP1B1::PRKACA gene fusion

Invasive squamous cell carcinoma arising from an intraductal oncocytic papillary neoplasm demonstrating shared ATP1B1::PRKACA gene fusion

Blog Article

Intraductal oncocytic papillary neoplasms (IOPN) are rare cystic pancreatic neoplasms marked by oncocytic cells and intricate papillary structures.While typically slow-growing, approximately one-third of IOPN cases are associated with invasive adenocarcinoma.In this report, we present an extremely rare here case of invasive squamous cell carcinoma arising in the background of IOPN.A 74-year-old man underwent a central pancreatectomy due to an incidentally discovered cystic mass in the pancreatic body.Histological examination revealed IOPN with regions of invasive squamous cell carcinoma.

Next-generation sequencing identified the characteristic ATP1B1::PRKACA lovesense 3 fusion in both the IOPN and squamous cell carcinoma components.To the best of our knowledge, this is the first documented instance of invasive squamous cell carcinoma originating from an IOPN.